TABLE 2.

TOP 20 CPG SITES WITH SIGNIFICANT DIFFERENTIAL METHYLATION BY CURRENT SYSTEMIC STEROID USE (MODEL 1)

		ICGN		EOCOPD
CpG names	Gene Symbol	Difference in Mean Methylation*	P Value†	Difference in Mean Methylation*	P Value‡	Liptak Combined P Value
cg19906550	SLC22A18	−0.10	5.96 × 10−35	−0.05	3.56 × 10−4	4.71 × 10−37
cg27461196	FXYD1	−0.15	1.80 × 10−33	−0.08	3.40 × 10−4	1.27 × 10−35
cg25600606	HIPK3	−0.15	9.29 × 10−34	−0.08	7.95 × 10−4	1.76 × 10−35
cg08700306	LRP3	−0.09	3.60 × 10−33	−0.05	2.85 × 10−4	2.07 × 10−35
cg09868035	ABHD16B	−0.09	7.93 × 10−33	−0.05	1.47 × 10−3	2.97 × 10−34
cg17709873	LTA	0.10	3.36 × 10−32	0.06	7.32 × 10−4	5.32 × 10−34
cg01526089	P2RX1	−0.13	5.38 × 10−33	−0.06	3.52 × 10−3	6.29 × 10−34
cg00795812	PDCD1	0.09	7.21 × 10−33	0.05	4.05 × 10−3	1.01 × 10−33
cg18884741	RABGEF1	−0.17	1.98 × 10−32	−0.07	7.69 × 10−3	6.61 × 10−33
cg07730301	ALDH3B1	−0.10	3.29 × 10−31	−0.05	1.06 × 10−3	7.58 × 10−33
cg26215727	SCNN1A	−0.09	2.33 × 10−29	−0.05	4.82 × 10−5	2.13 × 10−32
cg21019522	SLC22A18	−0.08	2.50 × 10−29	−0.04	5.59 × 10−4	2.60 × 10−31
cg06270401	DYRK4	−0.12	1.10 × 10−29	−0.06	2.69 × 10−3	7.14 × 10−31
cg25634666	FOLR3	−0.11	6.60 × 10−29	−0.06	8.15 × 10−4	1.02 × 10−30
cg00974864	FCGR3B	−0.11	2.50 × 10−28	−0.06	5.92 × 10−4	2.68 × 10−30
cg08368934	GPR97	−0.10	5.13 × 10−29	−0.06	2.36 × 10−3	2.71 × 10−30
cg17823175	AZU1	−0.12	1.41 × 10−27	−0.07	1.62 × 10−4	4.00 × 10−30
cg00645579	IRF7	−0.09	2.08 × 10−27	−0.05	6.08 × 10−4	2.23 × 10−29
cg15518883	SIT1	0.08	4.44 × 10−27	0.05	3.03 × 10−4	2.32 × 10−29
cg24211388	AIF1	−0.12	3.02 × 10−28	−0.06	5.40 × 10−3	4.29 × 10−29

Definition of abbreviations: EOCOPD = Early Onset COPD Study; ICGN = International COPD Genetics Network.

^*Difference in mean methylation = (mean methylation subjects on steroids) − (mean methylation subjects not on steroids). Methylation values may range from 0 to 1.

^†P value from regression Model 1 (adjusted for age, sex, and FEV₁ % predicted)

^‡One-sided P value from regression Model 1.