Table 2.
Immunohistochemical quantification of epithelial cell types in guinea pig tracheas and intra-lobar small bronchioles.a
| Part of tracheab | Basal cells (%) | Ciliated cells (%) | Goblet cells (%) | Clara cellsc (%) |
|---|---|---|---|---|
| Proximalb | 25.2 ± 2.1 | 36.5 ± 4.3 | 19.4 ± 2.0 | 1.8 ± 0.8 |
| Distalb | 14.7 ± 1.1 | 42.6 ± 1.9 | 11.2 ± 1.5 | 17.7 ± 4.7 |
| Bronchiolard | 0e | 21.8 ± 4.3 | 1.7 ± 0.7 | 65.2 ± 7.4 |
a
Steady-state non-SPF guinea pig lungs were used in this study. Values represent the mean ± SD (standard deviation) from eighteen independent stained samples from six animals. At least 1000 cells were evaluated for each sample.
b
The epithelia of first three cartilage rings and the last three cartilage rings of tracheas were evaluated as proximal and distal parts of trachea in this study, respectively.
c
IHC staining of CCSP positive cells.
d
Intra-lobar small bronchiolar epithelium.
e
Small bronchiolar epithelium negative for K14 (basal cell marker).