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. Author manuscript; available in PMC: 2013 Apr 10.
Published in final edited form as: Blood. 2011 May 31;118(4):1041–1051. doi: 10.1182/blood-2011-02-338848

Figure 2. Activation of transposon mutagenesis in Etv6+/RUNX1 mice.

Figure 2

A. Western blot showing expression of the Sleeping Beauty transposase in the bone marrow of Etv6+/RUNX1 (ER) mice, but not mice carrying the T2Onc transposon (Onc). B. ‘Excision’ PCR showing mobilization of the transposon in bone marrow from Etv6+/RUNX1; T2Onc+/Tg (EROnc) mice, as evidenced by the 200 bp ‘excision’ band (instead of the 2 kb band seen in mice carrying the unmobilized transposon array, i.e., Etv6+/+; T2Onc+/Tg (Onc) mice). C. Kaplan-Meier curves showing the tumor latency of ‘jumping’ Etv6+/RUNX1; T2Onc+/Tg (EROnc) mice and ‘non-jumping’ control mice (ER, Onc and wildtype). D. Categorization of the malignancies developed by mice shown in the Kaplan-Meier curve according to the Bethesda criteria for lymphoid and non-lymphoid murine malignancies.25-26