Table 1. Gaussian kernel convolution (GKC) common insertion sites (CIS) identified in all B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases.
CIS shown in bold are only found in the BCP-ALLs (n=15), not the other ALL cases. CIS that are not located within ± 150K base pairs of a gene are given the label ‘CIS’ followed by the chromosome and the peak location of the Gaussian kernel.
| Gene | Chr. | CIS leak location |
GKC scale (Kbps) |
Tumours with CIS |
Unique insertions |
Other genes in the CIS interval |
|---|---|---|---|---|---|---|
| CIS7:37320759 | 7 | 37320759 | 15 | 6 | 12 | - |
| Eif2a | 3 | 58350745 | 240 | 6 | 10 |
2810407C02Rik,
AC111080.1, AC119873.1, AC132302.1, AC142228.1, Commd2, Gm410, Pfn2, Rnf13, Serp1, Siah2, Tsc22d2, U6, Wwtr1 |
| Ikzf1 | 11 | 11652893 | 15 | 4 | 9 | - |
| Epor | 9 | 21769506 | 15 | 2 | 9 | - |
| Cebpa | 7 | 35899198 | 15 | 2 | 8 | 5S_rRNA |
| Cnr2 | 4 | 135467435 | 15 | 4 | 7 | - |
| Prr8 | 5 | 28716988 | 75 | 5 | 6 |
AC121843.1,
AC134530.1, Shh |
| Rcan2 | 17 | 44101905 | 75 | 3 | 6 | 7SK, CT025668.2 |
| CIS6:31099937 | 6 | 31099937 | 30 | 5 | 5 |
AB041803,
AC153820.1/4, RP23-459L15.3 |
| Rasgrf1 | 9 | 89867811 | 15 | 5 | 5 | - |
| Slc10a1 | 12 | 82095071 | 15 | 5 | 5 | Sfrs5 |
| Gm1968 | 16 | 29983555 | 30 | 5 | 5 |
CT025592.1,
CT030736.1 |
| Mecom | 3 | 30047667 | 15 | 4 | 5 | - |
| Psd3 | 8 | 70258943 | 30 | 4 | 5 |
AC109142.1,
AC109142.2 |
| Sfi1 | 11 | 3065855 | 50 | 4 | 5 |
AL671968.1/2/4/5,
Drg1, Eif4enif1 |
| CIS5:75770426 | 5 | 75770426 | 15 | 3 | 5 | U6 |
| Raf1 | 6 | 115605310 | 120 | 2 | 5 | - |
| Kctd2 | 11 | 115288407 | 15 | 1 | 5 | - |
| CIS11:54066112 | 11 | 54066112 | 15 | 3 | 4 | AL596103.1, Il3 |
| Asap1 | 15 | 64063966 | 30 | 3 | 4 | - |
| Met | 6 | 17424888 | 15 | 2 | 4 | - |
| Fam46d | X | 105018631 | 15 | 2 | 4 | 2610002M06Rik |
| Csf2rb2 | 15 | 78135922 | 15 | 1 | 4 | - |
| CIS2:131423786 | 2 | 131423786 | 15 | 3 | 3 | - |
| Zmym4 | 4 | 126594535 | 15 | 3 | 3 | - |
| Zfp423 | 8 | 90421110 | 15 | 3 | 3 | - |
| Mef2c | 13 | 83672435 | 15 | 3 | 3 | - |
| Il2rb | 15 | 78328305 | 15 | 3 | 3 | - |
| Rasgef1a | 6 | 118007445 | 15 | 2 | 3 | - |
| L3mbtl3 | 10 | 26098605 | 15 | 2 | 3 | - |
| CIS10:116095924 | 10 | 116095924 | 15 | 2 | 3 | - |
| Thg1l | 11 | 45761354 | 15 | 1 | 3 | - |
| Gata1 | X | 7537541 | 15 | 2 | 2 | - |