Table 2.
Baseline demographics
|
DURATION-4* |
DURATION-2† |
DURATION-3‡ |
||||||
---|---|---|---|---|---|---|---|---|---|
ExQW | Met | Sita | Pio | EQW | Sita | Pio | ExQW | IG | |
N |
248 |
246 |
163 |
163 |
160 |
166 |
165 |
233 |
223 |
Sex (Male) (%) |
56 |
63 |
58 |
60 |
56 |
52 |
48 |
52 |
55 |
Race (%) |
|
|
|
|
|
|
|
|
|
American Indian or Alaska Native |
<1 |
1 |
1 |
0 |
0 |
2 |
0 |
0 |
0 |
Asian |
22 |
21 |
20 |
21 |
23 |
25 |
24 |
6 |
6 |
Black or African American |
3 |
5 |
2 |
3 |
12 |
12 |
8 |
1 |
>1 |
Hispanic |
7 |
9 |
8 |
9 |
31 |
30 |
27 |
12 |
9 |
Other |
0 |
<1 |
0 |
0 |
1 |
1 |
2 |
0 |
0 |
White |
68 |
65 |
69 |
68 |
33 |
30 |
39 |
82 |
85 |
Age (y) |
54 ± 11 |
54 ± 11 |
52 ± 11 |
55 ± 11 |
52 ± 10 |
52 ± 11 |
53 ± 10 |
58 ± 10 |
58 ± 9 |
Duration of diabetes (y) |
3 ± 3 |
3 ± 4 |
3 ± 4 |
3 ± 4 |
6 ± 5 |
5 ± 5 |
6 ± 6 |
8 ± 6 |
8 ± 6 |
Baseline weight (kg) |
87 ± 19 |
86 ± 20 |
89 ± 19 |
86 ± 18 |
89 ± 20 |
87 ± 20 |
88 ± 21 |
91 ± 19 |
91 ± 16 |
Baseline BMI (kg/m2) |
31 ± 5 |
31 ± 5 |
32 ± 5 |
31 ± 5 |
32 ± 5 |
32 ± 5 |
33 ± 6 |
32 ± 5 |
32 ± 5 |
Baseline HbA1c (%) |
8.5 ± 1.2 |
8.6 ± 1.2 |
8.5 ± 1.3 |
8.5 ± 1.2 |
8.6 ± 1.2 |
8.5 ± 1.2 |
8.5 ± 1.1 |
8.3 ± 1.1 |
8.3 ± 1.0 |
Baseline FBG (mmol/L) |
9.9 ± 2.9 |
10.0 ± 3.4 |
9.7 ± 2.6 |
9.8 ± 3.0 |
9.2 ± 2.9 |
9.1 ± 2.5 |
9.1 ± 2.4 |
9.9 ± 2.5 |
9.7 ± 2.7 |
Baseline SBP (mm Hg) |
129 ± 12 |
129 ± 15 |
130 ± 13 |
131 ± 15 |
126 ± 14 |
126 ± 14 |
127 ± 14 |
135 ± 17 |
133 ± 16 |
Baseline LDL (mmol/dL) |
3.1 ± 1.1 |
2.9 ± 0.9 |
3.0 ± 0.9 |
3.1± 1.0 |
2.6 ± 0.8 |
2.8 ± 0.9 |
2.9 ± 1.0 |
2.7 ± 0.9 |
2.7 ± 0.9 |
Background therapy (n) |
|
|
|
|
|
|
|
|
|
Metformin |
|
|
|
|
160 |
166 |
165 |
164 |
157 |
Diet and Exercise |
248 |
246 |
163 |
163 |
|
|
|
|
|
Metformin + Sulfonylurea | 69 | 66 |
*†‡Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once-Weekly-4, -2, -3 [23-25].
Values are shown as mean ± SD.
BMI , body mass index; DBP, diastolic blood pressure; ExQW, exenatide QW; HDL, high density lipoprotein cholesterol; IG, insulin glargine; Met, metformin; Pio, pioglitazone; Sita, sitagliptin.