Fig. 4.

Developmental expression profile from birth to adulthood in wild-type mouse lung of 11 genes with expression found to be increased by FGF18-transgene induction in microarray analysis. Quantitative RT-qPCR was used to determine expression levels. Endogenous-FGF18 expression profile is also displayed for facilitating comparisons. Mean ± se on 4 individual lung samples from 2 different litters per stage (absence of error bar means that it was too small to be represented at this scale). Multiple stage comparison was made by Kruskal-Wallis analysis, followed by two-stage comparisons by Mann and Whitney U test. To avoid overloading of the graphs, significant differences are not represented, but significant changes are detailed in text. Gene symbols: Adm, adrenomedullin: Hsd11b1, hydroxysteroid 11β dehydrogenase 1; Gstm5, glutathione-S transferase, mu5; Wnt2, wingless-related MMTV integation site 2, Snai, snail homolog, Ptger2, prostaglandin R receptor EP2 subtype.