Table 4.
Results of array analysis: genes up regulated at least 25%* by FGF18 induction in the 4 double-transgenic mouse pups as compared to their respective littermate single-transgenic controls (one-tailed paired t test).
| Accession # | Name | Funct. Cat. | log2-fold change | fold change | P value |
|---|---|---|---|---|---|
| NM_009627 | adrenomedullin (Adm) | Signal, Angio | 2.02628 | x 4.074 | 0.0494 |
| NM_007643 | CD36 antigen | Lmetab+Antifib | 1.06464 | x 2.092 | 0.0463 |
| NM_008288 | hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1) | Enz, Ster metab | 1.00447 | x 2.0 | 0.0364 |
| NM_008318 | bone sialoprotein (integrin-binding sialoprotein, IBSP) | ECM+Recept | 0.83998 | x 1.79 | 0.014 |
| NM_010360 | glutathione S-transferase, mu 5 (Gstm5) | Enz, Antiox | 0.75917 | x 1.693 | 0.0379 |
| NM_007752 | ceruloplasmin (Cp) | Enz, Antiox | 0.72622 | x 1.654 | 0.0393 |
| NM_023653 | wingless-related MMTV integration site 2 (Wnt2) | Signal, Angio+Migr | 0.58788 | x 1.5 | 0.0357 |
| NM_029796 | leucine-rich alpha-2-glycoprotein 1 (Lrg1) | Antiox | 0.55743 | x 1.472 | 0.0028 |
| NM_021282 | cytochrome P450, 2e1, ethanol inducible (Cyp2e1) | Enz, Antiox | 0.55580 | x 1.47 | 0.0305 |
| BI964347 | a disintegrin and metalloproteinase domain 12 (meltrin alpha) | Enz, ECM | 0.54291 | x 1.457 | 0.0283 |
| NM_033037 | cysteine dioxygenase 1, cytosolic (Cdo1) | Enz, Antiox | 0.51247 | x 1.426 | 0.037 |
| AF333251 | Th2-specific cytokine FISP/IL24 | Signal, Antifib | 0.48965 | x 1.4 | 0.0417 |
| NM_010023 | dodecenoyl-Coenzyme A delta isomerase (Dci) | Enz, Lmetab | 0.48113 | x 1.4 | 0.0077 |
| C77655 | CD84 antigen | Immun | 0.46537 | x 1.381 | 0.0311 |
| NM_011415 | snail homolog 2 (Drosophila) (Snai2) | Signal, Migr+EMT | 0.45841 | x 1.374 | 0.0412 |
| NM_010180 | fibulin 1 (Fbln1) | ECM+Antifib | 0.45225 | x 1.368 | 0.0354 |
| BB131147 | Borg4-pending/binder of Rho GTPase 4 | Recept, Antifib | 0.44920 | x 1.365 | 0.0261 |
| BQ176864 | protein phosphatase 1, regulatory (inhibitor) subunit 3C (Ppp1r3c) | Enz, Glyc metab | 0.43991 | x 1.357 | 0.0408 |
| BC028307 | Similar to sushi-repeat protein | Migr | 0.43074 | x 1.348 | 0.0257 |
| NM_010717 | LIM-domain containing, protein kinase (Limk1) | Enz, Antifib | 0.42335 | x 1,341 | 0,006 |
| NM_011146 | peroxisome proliferator activated receptor gamma (Pparg) | Signal, Lmetab | 0.41266 | x 1.331 | 0.0425 |
| NM_008118 | gastric intrinsic factor (Gif) | Transport | 0.38563 | x 1.306 | 0.0403 |
| NM_008059 | G0G1 switch gene 2 (G0s2) | Prolif | 0.37920 | x 1.3 | 0.0334 |
| X14607 | lipocalin 2/Mouse SV-40 induced 24p3 mRNA | Migr | 0.35332 | x 1.277 | 0.0197 |
| NM_011611 | tumor necrosis factor receptor superfamily, member 5 (Tnfrsf5) | Signal, Immun | 0.33640 | x 1.263 | 0.0425 |
| NM_023323 | brix domain containing 1 (Bxdc1) | Prolif | 0.33067 | x 1.258 | 0.0237 |
| BC008277 | Similar to Endothelin receptor type A | Recept, Angio | 0.32332 | x 1.251 | 0.0207 |
| NM_008964 | prostaglandin E receptor EP2 subtype (Ptger2) | Recept, Antifib | 0.31244 | x 1.242 | 0.0427 |
| NM_019389 | chondroitin sulfate proteoglycan 2 (Cspg2) | ECM | 0.30793 | x 1.238 | 0.0234 |
| NM_080849 | NIMA-related expressed kinase 8 (Nek8) | Enz, Prolif | 0.29273 | x 1.225 | 0.0356 |
| NM_007996 | adrenodoxin | Antiox | 0.29229 | x 1.225 | 0.0264 |
| NM_011427 | snail homolog 1, (Drosophila) (Snai1) | Signal, Migr+EMT | 0.29147 | x 1.224 | 0.0213 |
Five genes of interest increased 22.4 to 24.2% have been added to the list.
Abbreviations: Funct. Cat., functional category of gene product; Angio, angiogenesis; Antifib, anti-fibrotic effects; Antiox, anti-oxidant metabolism; ECM, extracellular-matrix component or metabolism; EMT, epithelial-mesenchymal transition; Enz, enzyme or enzyme inhibitor; Glyc metab, glycogene megtabolism; Immun, immune system; Lmetab, lipid metabolism; Migr, cell migration; Prolif, cell proliferation; Recept, receptor; Signal, signaling molecule; Ster metab, steroid metabolism; Transport, transporter molecule.
Genes with name and symbol in bold character had changes checked by RT-qPCR.