Table 1.
Characteristics of the SOF Cohort at Baseline, and Over 10 Years of Follow-up
| Risk Factors Used in FRAX Model: | Normala (n=1154) | Low Bone Massa (n=3791) | Osteoporotica (n=1307) | p |
|---|---|---|---|---|
| Age (years) | 69.6 (4.0) | 71.1 (4.8) | 73.6 (5.9) | <.001 |
| Sex – Female | 100% | 100% | 100% | — |
| BMI, kg/m2 | 29.0 (5.2) | 26.5 (4.3) | 24.1 (3.6) | <.001 |
| Rheumatoid Arthritis – Ever | 67 (5.8) | 258 (6.8) | 104 (8.0) | .11 |
| Steroid Use – Ever | 146 (12.7) | 432 (11.4) | 163 (12.5) | .38 |
| Smoking – Current | 90 (7.8) | 347 (9.2) | 146 (11.2) | .01 |
| Alcohol Use – >=3 Drinks/day | 46 (4.0) | 109 (2.9) | 29 (2.2) | .03 |
| Fracture of Any Bone After Age 50 | 253 (21.9) | 1251 (33.0) | 651 (49.8) | <.001 |
| History of Parental Hip Fracture | 132 (11.4) | 557 (14.7) | 236 (18.1) | <.001 |
| Femoral Neck BMD – T-score | −0.32 (0.66) | −1.79 (0.41) | −2.90 (0.33) | — |
| Other Variables and Outcomes: | ||||
| Femoral Neck BMD, g/cm2 | 0.82 (0.08) | 0.64 (0.05) | 0.51 (0.04) | |
| Total Hip BMD, g/cm2 | 0.93 (0.10) | 0.76 (0.08) | 0.61 (0.08) | |
| Years Follow-up | 9.6 (1.3) | 9.5 (1.4) | 9.1 (1.8) | |
| Hip Fractures - Observed | 14 (1.2) | 176 (4.7) | 178 (14.3) | <.001 |
| Hip Fractures – Predicted b | 11 (0.9) | 153 (4.0) | 170 (13.0) | |
| Major Osteoporotic Fractures - Observed | 71 (6.3) | 569 (15.7) | 371 (30.0) | <.001 |
| Major Osteoporotic Fractures – Predicted c, d | 115 (10.0) | 615 (16.2) | 376 (28.8) | |
Data are presented as mean (SD) or n (%).
a
Based on initial femoral neck T-score
b
Using FRAX hip fracture probability with BMD
c
Using FRAX major osteoporotic fracture probability with BMD
d
Major osteoporotic fractures include hip, clinical spine, wrist and humerus(6)