Table 3.
FRAX Prediction of Hip Fracture among 4097 Women Without a History of Prior Fracture
| Normal/LBM (n=3441) | Osteoporotic (n=656) | p-value | |
|---|---|---|---|
| Models if no Prior Fracture History: | AUC (95% CI) | AUC (95% CI) | |
| Hip Fracture n | 105 | 76 | |
| Age <=75 | |||
| FRAX with BMD | 0.75 (0.69, 0.80) | 0.60 (0.51, 0.70) | 0.01 |
| FRAX without BMD | 0.62 (0.56, 0.69) | 0.60 (0.51, 0.70) | 0.75 |
| Age+BMD | 0.73 (0.68, 0.79) | 0.59 (0.50, 0.69) | 0.01 |
| Age alone | 0.63 (0.57, 0.69) | 0.58 (0.48, 0.67) | 0.34 |
| Age >75 | |||
| FRAX with BMD | 0.66 (0.58, 0.73) | 0.51 (0.41, 0.60) | 0.02 |
| FRAX without BMD | 0.62 (0.53, 0.71) | 0.49 (0.39, 0.59) | 0.06 |
| Age+BMD | 0.69 (0.61, 0.77) | 0.62 (0.52, 0.71) | 0.22 |
| Age alone | 0.51 (0.41, 0.62) | 0.52 (0.42, 0.63) | 0.89 |
N=4097 women without a prior history of fracture. Although the age distribution for the whole cohort was approximately evenly split for age <=75 vs. age >75, for women without a history of fracture there were 3,427 women age <75 and 670 women who were age >75 at baseline. All BMD models use femoral neck BMD.