Fig. 3.

Apocynin prevents the decrease in beta cell function induced by oleate in vivo during two-step hyperglycaemic clamp in rats. Rats were treated as described in the Fig. 1 legend. Plasma levels of NEFA (a), glucose (b), insulin (d) and C-peptide (e) and glucose infusion rate (Ginf) (c) were measured during the two-step hyperglycaemic clamp. Data are means ± SEM (saline [SAL], n = 8; oleate [OLE], n = 8; OLE + apocynin [APO], n = 5; APO, n = 7); **p < 0.01 OLE vs SAL, ***p < 0.001 OLE vs SAL, ^† p < 0.05 OLE vs OLE + APO, ^‡‡ p < 0.01 OLE vs all. White circles, SAL; black circles, OLE; black squares, OLE + APO; white squares, APO