Fig. 5.

The genetic deletion of p47^phox in mice prevents oleate-induced beta cell dysfunction ex vivo in isolated islets. (a) Insulin secretory response to glucose and (b) islet insulin content in freshly isolated islets of p47^phox-null mice (KO) and their WT littermate controls treated as described in the Fig. 4 legend. Data are means ± SEM (WT-saline [SAL], n = 8; WT-oleate [OLE], n = 7; KO-OLE, n = 7; KO-SAL, n = 6); **p < 0.01 KO-OLE vs WT-SAL, ^‡‡ p < 0.01 WT-OLE vs all