Table 3.
Associations between type 2 diabetes CpG-SNPs that exhibit differential DNA methylation and mRNA expression in human pancreatic islets
| Chr. | SNP ID | Gene | SNP location | Genotype | n | Gene expression | ||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | β (SEM) | p value | ||||||
| 17 | rs391300 | RPA1 | ∼413.4 kb down | A A | 12 | 574.3 ± 54.3 | −0.056 (0.027) | 0.040 |
| A G | 47 | 562.1 ± 57.4 | ||||||
| G G | 22 | 537.1 ± 60.5 | ||||||
| X | rs5945326 | AVPR2 | ∼268.1 kb up | A A | 50 | 66.8 ± 9.0 | −0.052 (0.024) | 0.034 |
| A G | 9 | 64.1 ± 5.1 | ||||||
| G G | 22 | 62.3 ± 8.7 | ||||||
Data are expressed as mean ± SD of unlogged gene expression values
β (SEM) and p values are based on a linear regression of log2 values of gene expression adjusted for age, sex, BMI, islet purity and islet culture days
Chr., chromosome