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Schematics of effects of low concentrations of S100B on axonal regeneration of crushed peripheral nerves. S100B secreted/released from activated Schwann cells stimulates recruitment of Schwann cells and macrophages to the injury site and release of cytokine and trophic factors leading to axonal regeneration, in a receptor for advanced glycation end-products -dependent manner. RAGE: Receptor for advanced glycation end-products.
