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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Cell Signal. 2013 Feb 14;25(5):1156–1165. doi: 10.1016/j.cellsig.2013.02.005

Figure 8. Schematic depicting RKIP regulation of MAPK pathway in MEFs.

Figure 8

(A) In normal conditions, activation of growth factor receptors (GFR) lead to activation of the MAPK (ERK) pathway mainly through B-Raf. In this condition Raf-1 is repressed by RKIP and only marginally participates in the signaling. (B) When B-Raf is depleted or deficient, signaling through MAPK is severely hindered since RKIP prevents full activation of Raf-1 and downstream phosphorylation of ERK. (C) When RKIP and B-Raf are deficient or depleted, signaling to ERK occurs through Raf-1. The thickness of the blue arrows is proportional to the intensity of the signaling.