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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Pain. 2013 Jan 30;154(5):733–742. doi: 10.1016/j.pain.2013.01.012

Figure 3. IT administration of TLR ligands in C57Bl/6 mice produced robust TA.

Figure 3

TLR ligands were spinally delivered via IT injection at the L5 level in C57Bl/6 mice. The effect of intrathecal (IT) administration of TLR ligands (Supplemetary Figure 2) on tactile thresholds was measured by von Frey filament testing, using the up-down method (A–D). Data expressed as mean ± SEM (n=5–8 mice/group) and analyzed via 2-way ANOVA, followed by Bonferroni post hoc test to compare each time point to the IT saline group (*p<0.05; **p<0.01). The same IT saline group is represented in all four graphs.