Table 3.
Offspring and maternal xenobiotic metabolism haplotypes and the risk of childhood ALL, single and double dose haplotype effects
| Gene | Haplotype | Frequency (95% CI) | Offspring haplotype relative risk1 (95% CI) | Maternal haplotype relative risk1 (95% CI) | P-value2 | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Single-dose | Double-dose | Single-dose | Double-dose | ||||
|
|
|||||||
| CYP1B13 | C-A | 0.35 (0.24, 0.48) | 1.17 (0.55, 2.51) | 1.43 (0.46, 4.43) | 1.49 (0.70, 3.09) | 2.80 (0.99, 7.70) | 0.62 |
| g-A | 0.43 (0.32, 0.56) | 0.78 (0.39, 1.55) | 0.77 (0.27, 2.17) | 1.40 (0.65, 2.99) | 1.58 (0.55, 4.50) | ||
| C-g | 0.21 (0.12, 0.33) | 1.08 (0.53, 2.22) | 1.51 (0.35, 6.52) | 0.60 (0.31, 1.22) | 0.80 (0.21, 2.93) | ||
| EPHX14 | c-A | 0.20 (0.12, 0.31) | 2.64 (1.15, 6.01) | 5.84 (1.75, 20.10) | 1.99 (0.91, 4.49) | 2.81 (0.79, 10.10) | 0.05 |
| T-A | 0.56 (0.43, 0.68) | 1.80 (0.65, 5.07) | 2.18 (0.62, 7.83) | 0.48 (0.24, 0.98) | 0.46 (0.17, 1.23) | ||
| T-g | 0.24 (0.13, 0.37) | 0.33 (0.15, 0.71) | 0.14 (0.01, 1.26) | 0.88 (0.39, 1.92) | 0.77 (0.13, 4.65) | ||
| GSTA45 | c-c | 0.20 (0.12, 0.32) | 0.47 (0.22, 1.01) | 0.16 (0.02, 1.62) | 1.19 (0.57, 2.42) | 1.42 (0.31, 6.57) | 0.50 |
| c-T | 0.24 (0.15, 0.35) | 1.94 (0.92, 4.23) | 2.79 (0.75, 10.30) | 0.63 (0.32, 1.25) | 0.72 (0.22, 2.37) | ||
| G-T | 0.55 (0.43, 0.67) | 1.46 (0.61, 3.61) | 1.60 (0.53, 4.91) | 1.96 (0.73, 5.43) | 2.12 (0.65, 6.92) | ||
| GSTM3/GSTM46 | a-c | 0.10 (0.05, 0.19) | 0.90 (0.37, 2.22) | 1.45 (0.26, 7.85) | 2.38 (1.04, 5.46) | 10.40 (2.36, 47.60) | 0.01 |
| G-c | 0.22 (0.13, 0.34) | 1.15 (0.53, 2.51) | 3.11 (0.89, 10.10) | 0.88 (0.42, 1.86) | 1.32 (0.39, 4.36) | ||
| a-G | 0.17 (0.09, 0.28) | 1.88 (0.80, 4.45) | 2.19 (0.42, 10.70) | 0.61 (0.30, 1.24) | 1.56 (0.47, 5.29) | ||
| G-G | 0.50 (0.37, 0.62) | 0.46 (0.23, 0.93) | 0.50 (0.18, 1.38) | 0.78 (0.37, 1.64) | 0.82 (0.29, 2.37) | ||
| GSTP17 | A-C | 0.80 (0.68, 0.89) | -- | REF8 | -- | REF8 | 0.02 |
| g-C | 0.20 (0.11, 0.32) | 2.67 (1.27, 5.54) | 3.66 (0.89, 13.70) | 1.22 (0.68, 2.21) | 3.69 (1.32, 10.00) | ||
1
Comparison of the specific haplotype compared to the reference group of the remaining haplotypes
2
Likelihood ratio test P-value of overall effect
3
Haplotype of SNP rs1056836 and rs1800440
4
Haplotype of SNP rs1051740 and rs2234922
5
Haplotype of SNP rs316133 and rs3756980
6
Haplotype of SNP rs1571858 and rs1010167
7
Haplotype of SNP rs1138272 and rs1695
8
With two haplotypes, the model compares the g-C/A-C (single-dose) and g-C/g-C (double dose) against the reference A-C/A-C