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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Hepatology. 2013 Jan 18;57(4):1575–1584. doi: 10.1002/hep.26134

Figure 2. Increased APAP-protein adducts in CD1d−/− mice compared to WT mice following APAP-challenge.

Figure 2

Female CD1d−/− and WT mice were starved overnight prior to i.p. injected with APAP (350 mg/kg). After 2 h, mice were sacrificed and livers harvested. A) APAP-protein adducts in liver homogenates and B) mitochondrial fractions were probed using anti-APAP antisera (1:5000; gift from Dr. Lance Pohl, National Institutes of Health, Bethesda, MD). Quantification of APAP-protein adducts in C) liver homogenates and D) mitochondrial fractions by densitometric analysis. Results represent mean ± SEM of 3 mice per group. * p < 0.05 versus WT mice. Data shown are representative of three independent experiments.