Table 2.
SLN Identification Results
| Characteristic | Total (24 subjects) | ICG:HSA (12 subjects) | ICG alone (12 subjects) | P | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| N | % | N | % | N | % | ||
|
| |||||||
| SLNs detected by lymphoscintigraphy | .41 | ||||||
| Unilateral | 14 | 42 | 6 | 50 | 8 | 67 | |
| Bilateral | 10 | 58 | 6 | 50 | 4 | 33 | |
|
| |||||||
| Intraoperative detection rate* | |||||||
| Per patient | 19 | 79 | 10 | 83 | 9 | 75 | .61 |
| Per groin† (34 groins) | 25 | 74 | 15 | 83 | 10 | 63 | .17 |
|
| |||||||
| Average number of intraoperative identified SLNs per patient ± SD | 1.5 ± 1.2 | 1.9 ± 1.4 | 1.0 ± 0.7 | .06 | |||
|
| |||||||
| Number of SLNs identified | 35 | 23 | 12 | ||||
|
| |||||||
| Method of SLN detection | |||||||
| Radioactive | 35 | 100 | 23 | 100 | 12 | 100 | |
| Fluorescence | 35 | 100 | 23 | 100 | 12 | 100 | |
| Blue dye | 27 | 77 | 16 | 70 | 11 | 92 | .09 |
|
| |||||||
| Signal-to-background ratio | 10.7 ± 4.4 | 10.3 ± | 2.5 | 11.2 ± 6.0 | .65 | ||
|
| |||||||
| Average time between injection and skin incision ± SD (min) | 17 ± 6 | 18 ± 6 | 16 ± 6 | .39 | |||
|
| |||||||
| Average time between skin incision and first SLN detection ± SD (min) | 10 ± 9 | 10 ± 9 | 11 ± 8 | .75 | |||
|
| |||||||
| Histology | .50 | ||||||
| negative | 17 | 71 | 8 | 67 | 9 | 75 | |
| ITC/micrometastasis | 3 | 13 | 1 | 8 | 2 | 17 | |
| macrometastasis | 4 | 16 | 3 | 25 | 1 | 8 | |
ICG:HSA, indocyanine green (ICG) adsorbed to human serum albumin (HSA); SLN, sentinel lymph node; ITC, isolated tumor cells
*
Detection rate combining NIR fluorescence imaging, the gamma probe, and blue dye staining
†
Groins with SLN localization by preoperative lymphoscintigraphy (N=18 ICG:HSA, N=16 ICG alone)