Table 3.
Outcome Measures of Effectiveness in the Efficacy Evaluable Population - by incoming study medication
| Olanzapine
|
Quetiapine
|
Risperidone
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Switch (N=29) | Stay (N=35) | Difference (95% CI) | Switch (N=23) | Stay (N=28) | Difference (95% CI) | Switch (N=37) | Stay (N=35) | Difference (95% CI) | |
| Primary Outcome | |||||||||
|
| |||||||||
| Change in Framingham Risk Score | −0.020 ± 0.0055 | −0.010 ± 0.0040 | 0.010 (−0.003,0.023) | −0.024 ± 0.0062 | −0.009 ± 0.0053 | 0.015 (−0.002,0.031) | −0.014 ± 0.0042 | −0.010 ± 0.0045 | 0.004 (−0.009,0.016) |
|
| |||||||||
| Other Secondary Outcomes | |||||||||
| Metabolic Outcomes | |||||||||
|
| |||||||||
| Change in weight (kg) | −4.2 ± 0.88 | −1.0 ± 0.73 | 3.2 (1.0,5.4) | −2.2 ± 0.97 | −0.6 ± 0.85 | 1.6 (−0.9,4.1) | −4.0 ± 0.72 | −0.8 ± 0.74 | 3.3 (1.2,5.3) |
|
| |||||||||
| Change in LDL Cholesterol (mg/dL) | −26.1 ± 4.74 | −15.2 ± 3.75 | 10.9 (−0.6,22.5) | −10.7 ± 5.36 | −13.3 ± 4.78 | −2.6 (−16.4,11.2) | −10.1 ± 3.85 | −9.7 ± 4.12 | 0.4 (−10.3,11.1) |
|
| |||||||||
| Change in HDL Cholesterol (mg/dL) | 0.9 ± 1.38 | 0.3 ± 1.08 | −0.5 (−4.0,2.9) | −0.4 ± 1.55 | −0.1 ± 1.32 | 0.4 (−3.6,4.4) | 1.1 ± 1.12 | −0.7 ± 1.14 | −1.8 (−4.9,1.4) |
|
| |||||||||
| Change in Triglycerides (mg/dL) | −17.9 ± 14.43 | −0.6 ± 11.38 | 17.3 (−18.6,53.3) | −29.7 ± 16.49 | 12.6 ± 13.87 | 42.3 (0.5,84.0) | −31.4 ± 11.66 | 7.3 ± 11.89 | 38.6 (6.1,71.2) |
|
| |||||||||
| Change in TG/HDL ratio | −0.6 ± 0.45 | −0.1 ± 0.35 | 0.5 (−0.6,1.6) | −1.0 ± 0.51 | 0.4 ± 0.43 | 1.4 (0.1,2.7) | −0.9 ± 0.36 | 0.2 ± 0.37 | 1.1 (0.1,2.1) |
|
| |||||||||
| Change in fasting glucose (mg/dL) | 2.6 ± 2.58 | 4.5 ± 1.95 | 2.0 (−4.4,8.3) | 1.6 ± 2.94 | 7.0 ± 2.44 | 5.4 (−2.0,12.8) | −1.7 ± 2.05 | 1.1 ± 2.08 | 2.8 (−2.9,8.5) |
|
| |||||||||
| Waist circumference (inches) | −1.6 ± 0.45 | −0.8 ± 0.37 | 0.8 (−0.3,2.0) | −0.8 ± 0.50 | −0.4 ± 0.43 | 0.4 (−0.9,1.7) | −1.5 ± 0.36 | −0.2 ± 0.38 | 1.3 (0.3,2.3) |
|
| |||||||||
| Systolic blood pressure (mmHg) | −2.7 ± 2.46 | −4.0 ± 1.88 | −1.2 (−7.2,4.7) | −5.8 ± 2.76 | −0.5 ± 2.30 | 5.2 (−1.6,12.1) | −3.4 ± 1.94 | 0.7 ± 1.97 | 4.1 (−1.1,9.4) |
|
| |||||||||
| Diastolic blood pressure (mmHg) | −4.5 ± 1.96 | −3.1 ± 1.53 | 1.4 (−3.2,6.0) | −3.2 ± 2.19 | 0.7 ± 1.84 | 3.8 (−1.4,9.1) | −3.0 ± 1.57 | −2.5 ± 1.60 | 0.5 (−3.6,4.5) |