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(a) Positioning of side-chain residues on a canonical α-helix. (b–d) examples of protein complexes with hot spot residues on one face, two faces, and three faces. (b) Yersinia pestis YopN/TyeA complex, PDB code 1XL3; (c) ligand-binding domain (LBD) of the retinoid X receptor/coactivator complex (PDB code 1XIU); (d) E. coli sigma factor/anti-sigma RseA complex, PDB code 1OR7.
