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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Eur J Med Chem. 2013 Jan 11;62:40–50. doi: 10.1016/j.ejmech.2013.01.006

Scheme 1.

Scheme 1

Synthetic pathway to compounds 1–29 (Table 1). Reagents: (a) AlCl3 in CH2Cl2; (b) POCl3, dry THF. For compounds 8 and 17, cyclohexylamine was used to obtain the corresponding aroylacrylic acid amides (D). Benzylamine was used to obtain derivatives 9, 10, 15 and 17. For the rest of the compounds, aniline or substituted anilines were used.