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. 2013 Feb 14;21(4):181–186. doi: 10.1016/j.tim.2013.01.005

Figure 1.

Figure 1

Two viral proteins that bind ISG15. (a) Influenza NS1B–N-terminal domain region (NTR) homodimer (green and cyan chains) binds two human ISG15 molecules (magenta) via their N-terminal ubiquitin-like (Ubl) domains. Generated from the Protein Data Bank (PDB) ID: 3SDL. (b) The deconjugating viral ovarian tumor (OTU) domain of Crimean Congo hemorrhagic fever virus (CCHFV; green) bound to human ISG15 substrate (magenta). The viral OTU binds the C-terminal Ubl domain of ISG15 with the C-terminus trapped as covalent intermediate. Generated from PDB ID: 3PSE. The missing loop in the ISG15 N-terminal Ubl is shown with a dashed line.