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. 2013 Feb 14;21(4):181–186. doi: 10.1016/j.tim.2013.01.005

Figure 2.

Figure 2

Alignment of ISG15 sequences from four species: human, rhesus monkey, mouse, and dog. Generated from National Center for Biotechnology Information (NCBI) accession numbers: NP_005092, NP_001253735, NP_056598, and XP_003639101, respectively). The five-amino acid hinge between the N-terminal and C-terminal ubiquitin-like (Ubl) domains is enclosed in a red box. Dark blue shading denotes amino acids that are conserved in all four ISG15 molecules; lighter blue shading denotes amino acids that are present in three or two of the ISG15 molecules.