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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Acta Biomater. 2013 Jan 29;9(5):6393–6402. doi: 10.1016/j.actbio.2013.01.016

Figure 3.

Figure 3

Sacrificial PEO nanofibers deliver functional enzymes upon hydration. (A) Morphology of cell monolayers treated with eluant from fibers containing trypsin for 60 minutes as a function of fiber mass (n=2). Scale = 0.2 mm. (B) Proteoglycan removal from cartilage cylinders after 6 hours of incubation with BM or HBSS (controls) or eluant from PEO or PEO-T nanofibers (n=3). Scale = 0.5 mm. (C) % AB staining of proteoglycan in cartilage cylinders as a function of treatment group and time, normalized to BM controls (n=3). Dashed line indicates treatment with 1.25% w/v trypsin for 20 minutes as a positive control. * = p≤0.05 vs. other groups at 3 hours. ** = p≤0.05 vs. all other groups and time points.