Table 2.

Treatment of neurological disorders using human umbilical cord blood (UCB).

Neurological disorders	Effects after transplantation of UCB and UCB derived cells	Working mechanisms	Species	References	Clinical trial No.
Ischemia	Reduce the infract volume; Improve neurological performance	Migrate to the injured sites; Cell replacement; Angiogenesis; Growth factors mediated neuroprotection; Anti-apoptosis; Anti-inflammation	Mouse, rat	[36], [39-45], [48-64]	NCT01700166
Spinal Cord Injury	Promote regeneration; Recover locomotion	Migrate to the injured sites; Cell replacement; Growth factors mediated neuroprotection; Anti-apoptosis; Anti-inflammation	Rat	[37], [65-69]	NCT01046786
Parkinson's Disease	No reports in vivo	Differentiate into dopaminergic neurons; Cell replacement	Rat	[70, 71]
Alzheimer Disease	Prolong survival; Rescue cognitive impairment	Anti-inflammation; Anti-apoptosis; Reduce the levels of amyloid-β	Mouse	[72, 73]	NCT01297218, NCT01696591
Amyotrophic Lateral Sclerosis	Delay disease progression; Increase lifespan	Cell replacement; Neuroprotection	Mouse	[74,75]	NCT01494480