A. mDisc1 mice showed a significant increase in the excitation/inhibition ratio, suggesting an increase in the relative contribution of excitatory inputs to pyramidal neurons in mutant animals. When the ratios were separated by sex, mDisc1 males displayed a significant increase, while mDisc1 females did not. B. No difference occurred in the excitation/inhibition ratio in hDisc1 mice. When the ratios were separated by sex, hDisc1 males showed a significant increase in the excitation/inhibition ratio, while female hDisc1 mice did not.