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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Schizophr Res. 2013 Mar 6;146(0):264–272. doi: 10.1016/j.schres.2013.02.007

Figure 4. Glutamatergic and GABAergic synaptic activity in hDisc1 mice.

Figure 4

A. Typical traces of sEPSCs (−70 mV, with 5 µMBIC) from cortical pyramidal neurons. hDisc1 mice showed a significant increase in mean sEPSC frequency (inset) and frequency of events 5–15 pA. A significant difference occurred in the cumulative distributions of IEIs from 200–2900 ms. B. Typical traces of sIPSCs recorded in ACSF at a holding potential of+10 mV. No significant differences were observed in mean sIPSC frequency, amplitude-frequency histograms, or IEI cumulative distributions.