TABLE I.
Tested Markers and LOD Scores in Chromosomal Region 12q23 and 12q24
| Marker | Map position (cM) | Info (%) | LOD | Pointwise P-values | Empirical P-values |
|---|---|---|---|---|---|
| D12S1300 | 104.12 | 83.1 | 0.063 | 0.3 | 0.99 |
| D12S1706 | 104.13 | 83.0 | 0.062 | 0.3 | 0.99 |
| D12S1597 | 114.28 | 79.1 | 0.299 | 0.12 | 0.89 |
| D12S1613 | 116.08 | 78.9 | 0.547 | 0.06 | 0.56 |
| D12S1583 | 119.55 | 84.6 | 0.921 | 0.02 | 0.19 |
| D12S395 | 136.82 | 72.4 | 0.895 | 0.02 | 0.28 |
| D12S1612 | 140.17 | 92.5 | 1.180 | 0.01 | 0.14 |
| D12S1614 | 144.83 | 93.7 | 1.226 | 0.009 | 0.10 |
| D12S342 | 144.84 | 93.7 | 1.228 | 0.009 | 0.10 |
| D12S340 | 146.39 | 94.5 | 1.393 | 0.006 | 0.05 |
| D12S324 | 147.17 | 95.6 | 1.534 | 0.004 | 0.03 |
| D12S386 | 147.18 | 95.6 | 1.535 | 0.004 | 0.03 |
| D12S1639 | 148.24 | 95.4 | 1.891 | 0.002 | 0.003 |
| D12S1634 | 148.25 | 95.6 | 1.914 | 0.0015 | 0.003 |
| D12S1658 | 148.26 | 95.5 | 1.905 | 0.002 | 0.003 |
| GATA41E12 | 149.60 | 91.8 | 1.504 | 0.004 | 0.04 |
| D12S1675 | 150.70 | 91.4 | 1.504 | 0.004 | 0.04 |
| D12S1679 | 153.19 | 92.6 | 1.337 | 0.007 | 0.05 |
| D12S1609 | 153.33 | 91.0 | 1.301 | 0.007 | 0.07 |
| D12S1659 | 155.94 | 84.5 | 0.952 | 0.02 | 0.22 |
| D12S367 | 159.59 | 88.0 | 0.640 | 0.04 | 0.49 |
| D12S1045 | 160.68 | 87.0 | 0.474 | 0.07 | 0.72 |
| D12S63 | 163.55 | 75.6 | 0.263 | 0.14 | 0.94 |
Map position indicates genetic map positions obtained from Marshfield Clinic.
Info indicates information content at each marker position. Empirical P-values were obtained from 1,000 simulation replicates.