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. 2013 Apr 9;4(2):e00595-12. doi: 10.1128/mBio.00595-12

FIG 3 .

FIG 3 

HAdV-D60 interaction with host cellular integrins. (A) In vivo infection of HAdV-D60 in the presence of either a 15mer peptide containing Arg-Gly-Asp (RGD) motif or a control 15mer peptide containing Lys-Gly-Glu (KGE). Clinical pictures represent inflammation at 4 days postinfection. (B) Homology modeling of the pentameric structure of the HAdV-D60 penton base. The location of a Tyr-Gly-Asp (YGD) motif on the putative structure is identified in red. (C) In vitro entry of HAdV-D60 into human corneal fibroblasts in the presence of a 15mer peptide containing YGD or KGE. (D) CXCL8 expression in human corneal fibroblasts at 4 h after infection in vitro with HAdV-D60 in the presence of peptide containing either RGD, YGD, or KGE. (E) In vivo infection of HAdV-D60 in the presence of peptide containing either YGD or KGE. Clinical pictures (top) and hematoxylin and eosin (H&E)-stained tissue sections (bottom) show inflammation at 4 days postinfection. Error bars represent standard deviations. n = 3 for all experiments. *, P < 0.05 (ANOVA with preplanned contrasts).