Figure 6.

Laser scanning confocal images depicting the development of multiple pores and/or cavities in the double-walled PDLLA(PLGA) microspheres during the later stage of the degradation process (33 to 40 days). A composite z-stack consisting of 5 confocal sections of the same microspheres was captured based on a z-interval of 12.5 µm between images measured above and below the center plane of the microspheres. (a) and (c) are the confocal images of formulation A microspheres after 33 and 40 days of degradation respectively. (b) and (d) are the confocal images of formulation B microspheres after 33 and 40 days of degradation respectively. Scale bar = 50 µm.