Representative retroareolar regions of interest (ROI) from cranio-caudal (CC) mammographic images of unaffected breasts of cancer-affected and cancer-free women. A, C and E are pre-menopausal cases. B, D and F are post-menopausal cases. A, B, C, D, E and F represent ROI’s with low skewness (skewness = −1.5677), high skewness (skewness = 1.5942), high coarseness (coarseness = 9.1793E-4), low coarseness (coarseness = 1.2043E-4), high gray-level correlation (gray-level correlation= 0.9949) and low gray-level correlation (gray-level correlation = 0.8637) texture features respectively. In general, pre-menopausal women tend to have denser breast parenchyma with smoother texture; post-menopausal women have less dense parenchyma with sharper textures. These characteristics were quantitatively characterized using the implemented texture features. Shown are texture features that exhibited statistically significant differences between pre- and post-menopausal women.