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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Biomol Screen. 2012 Aug 24;18(1):26–38. doi: 10.1177/1087057112456875

Figure 2.

Figure 2

Representative synthetic route for compound 1. (A) methyl 3-(furan-2-yl)-3-oxopropanoate, AcOH, 100°C, 2 hr (65% yield). (B) POCl3, BnEt3NCl, PhNMe2, CH3CN, 80°C, 16 hr (84% yield). (C) furan-3-yl(piperazin-1-yl)methanone, DIPEA, CH3CN, 100 °C, 16 hr (99% yield). (D) diethylmalonate (21% yield) NaOEt, EtOH, 80°C, 3 hr (75% yield). (E) POCl3, N,N-dimethylaniline, 115°C, 16 hr (42% yield). (F) potassium aryltrifluoroborate salt, Pd(OAc)2, RuPhos, Na2CO3, EtOH, MWI, 90 °C, 6 hr.