Fig. 1.

Brain BACE1 protein levels and activity in ADAD, SAD patients and controls. BACE1 protein levels and activity were measured in brain homogenates from ADAD and SAD patients, and from young (YC) and elderly (EC) controls. There was an increase in BACE1 protein levels (a **p = 0.01) and activity (b *p = 0.04) in the frontal cortex of SAD cases compared to age-matched elderly controls. No differences were detected between ADAD cases and age-matched controls in either brain BACE1 protein levels or activity (p = 0.91 and p = 0.42, respectively). There was a significant increase in BACE1 protein levels (a *p = 0.03) but not in BACE1 activity (b, n.s., p = 0.12) in SAD relative to ADAD cases. Western blot analyses using the BACE-specific antibody BC05 confirmed the increased in BACE expression in SAD compared to ADAD (c) and the lack of differences between ADAD and controls (d). Representative blots are shown