Fig. 3.

Brain APP β-CTF levels are elevated in ADAD. APP β-CTF levels were measured in membrane fractions in brain homogenates from ADAD, SAD and controls (a). ADAD cases showed higher APP β-CTF levels than age-matched controls and SAD (**p < 0.01). These differences were confirmed by Western blot in samples from patients with ADAD, SAD and controls. APP CTF accumulation was observed in ADAD cases compared to age-matched controls (b) and to SAD cases (c, d). APP CTF accumulation was also observed by Western blot in SAD cases compared to controls despite the fact that it did not reach statistical significance in the ELISA assay (e)