Figure 3.

Social learning test in rats given morphine in presence of different signalling inhibitors. (A) Investigation times after systemic morphine (1 μg kg⁻¹) together with intra-AOB injection of the PLC inhibitor U73122 or its inactive analogue U-73333. (B) Investigation times after systemic morphine (1 μg kg⁻¹) with intra-AOB injection of calphostin C (PKC inhibitor). (C) Investigation times after systemic morphine (1 μg kg⁻¹) with intra-AOB injection of the PKA inhibitor H-89. Vertical bars represent SEM; **α < 0.01, significantly different from saline treatment or °°α < 0.01 familiar versus unfamiliar juvenile. The numbers shown in the Figure represent the number of animals used in each experiment.