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. 2013 Mar 25;168(8):1878–1888. doi: 10.1111/bph.12079

Figure 3.

Figure 3

In vivo treatment with HET0016 attenuates oxidative stress in MCA of SHR. (A) Representative images showing red nuclear DHE fluorescence, representing cellular O2.- production, in sections of MCAs of control WKY rats, SHRs and treated WKY and SHRs with HET0016 (10 mg·kg−1·per day, i.p.). (B) Summary data for nuclear DHE fluorescence intensities (n = 6 for each group). (C) Summary data showing the effect of 20-HETE (10−7 mol·L−1) on production of ROS of vascular ring preparations (n = 7) in the absence and presence of NADPH oxidase inhibitor apocynin (3 × 10−4 mol·L−1). Data are mean ± SEM *P < 0.05 versus control; #P < 0.05 versus untreated.