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Effects of acute morphine administration on DA and 3,4-Dihydroxyphenylacetic acid (DOPAC) levels at the NAc and on DA turnover (as estimated by the DOPAC/DA ratio). Data represent the mean ± SEM 1 and 2 h after morphine or saline injection to control pellets-treated rats. Newman–Keuls post hoc comparison test revealed a significant increase in DOPAC production and DA turnover in morphine (mor)-treated rats. **P < 0.01; ***P < 0.001 versus control pellets (placebo) + saline (sal).
