Table 2.
Colistin concentration-time data for the different study groupsa
| Study group | Day | Time (h) | No. of samples | Mean ± SD (ng/ml) (range) |
CSF/serum ratio | |
|---|---|---|---|---|---|---|
| Serum | CSF | |||||
| Control | 1 | 1 | 5 | 2,308 ± 348 | 152 ± 18 | 0.066 ± 0.002 |
| 4 | 5 | 1,491 ± 74 | 105 ± 11 | 0.070 ± 0.006 | ||
| 8 | 5 | 1,041 ± 135 | 76 ± 11 | 0.074 ± 0.002 | ||
| 3 | 1 | 3 | 2,039 ± 4 | 141 ± 17 | 0.069 ± 0.001 | |
| 8 | 1 | 1,033 | 72 | 0.070 | ||
| 5 | 1 | 1 | 2,013 | 137 | 0.068 | |
| EVDViv | 1 | 1 | 2 | 2,189 (1,922–2,455) | 237 (198–275) | 0.108 |
| 4 | 2 | 1,451 (1,405–1,498) | 156 (152–159) | 0.107 | ||
| 8 | 2 | 1,089 (930–1,248) | 120 (103–137) | 0.110 | ||
| 3 | 1 | 2 | 2,205 (2,097–2,313) | 254 (213–295) | 0.114 | |
| 8 | 2 | 1,001 (970–1,032) | 119 (117–120) | 0.118 | ||
| 5 | 1 | 1 | 2,449 | 259 | 0.106 | |
| 8 | 1 | 1,258 | 140 | 0.111 | ||
| EVDVcomb | 1 | 1 | 3 | 3,451 ± 221 | 1,449 ± 124 | 0.420 ± 0.012 |
| 4 | 1 | 1,838 | 838 | 0.456 | ||
| 8 | 1 | 1,523 | 621 | 0.408 | ||
| 3 | 1 | 1 | 3,144 | 1,357 | 0.432 | |
| 5 | 1 | 3 | 3,531 ± 202 | 1,430 ± 40 | 0.406 ± 0.012 | |
| 8 | 2 | 1,514 (1,415–1,612) | 611 (548–675) | 0.403 | ||
a
Data are presented as means ± SD or as otherwise indicated. EVDViv, external ventricular drainage-associated ventriculitis patients treated with i.v. colistin; EVDVcomb, external ventricular drainage-associated ventriculitis patients treated with combined i.v. and intraventricular colistin.