Fig 1.

Bactericidal effects of β-lactams on WT and efflux pump KO mutant M. tuberculosis strains. Shown are the bactericidal activity profiles of PSI for WT M. tuberculosis and the efflux pump KO mutants. The three concentrations used cover the range of MICs for the different KO strains in this study (WT, KO1, KO5, KO6, and KO7). The y axis represents the number of bacteria surviving under each concentration shown on the x axis after exposure to antibiotics for 7 days. The dashed line indicates the cell number for all of the strains at the start of the experiment, which was 5.5 ± 0.2 log₁₀ CFU/ml.