Table 1.
MICs of PSI for WT and efflux pump KO mutant strains of M. tuberculosis
| Antibiotic | MIC (μg/ml)a |
||||
|---|---|---|---|---|---|
| WT | KO1 | KO5 | KO6 | KO7 | |
| Penicillin G | 64 | 32 | 16 | 32 | 16 |
| Ampicillin | 16 | 4–8 | 8 | 8 | 4–8 |
| Meropenem | 2–4 | 1 | 1 | 2–4 | 2 |
| Ceftriaxone | 2–4 | 0.5–1 | 0.5–1 | 0.5–1 | 0.5–1 |
| Cefotaxime | 2–4 | 0.5–1 | 0.5–1 | 1–2 | 0.5 |
| Vancomycin | 2 | 0.5 | 1 | 1 | 0.5 |
| Bacitracin | >128 | >128 | 32 | >128 | 128 |
| Isoniazid | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 |
a
MICs were determined by the resazurin-based microplate assay. Each value is the average of at least three independent assays.