Table 4.
Emergent and resistance-associated amino acid substitutions detected in NA of influenza virus isolates
| Subject no. | Season | Virus type/subtype | IC50 (nM) | Incidence | Amino acid substitution(s) (N2 numbering) |
|---|---|---|---|---|---|
| 3, 4 | 2006-2007 | H1N1 | 0.5–1.0a | Nonemergent | G248Rc |
| 5 | 2006-2007 | B | 1.9–4.8b | Emergent, day 7 | L98L/F |
| 6 | 2007-2008 | H1N1 | NCe | Emergent, day 7 | T69T/I |
| 7 | 2007-2008 | H1N1 | NC | Emergent, day 3 | S367N |
| 8 | 2007-2008 | H1N1 | NC | Emergent, day 3 | S195Y |
| 9 | 2008-2009 | H1N1 | NC | Emergent, day 7 | N294Kd |
| 10 | 2008-2009 | H1N1 | NC | Emergent, day 6 | DEL110-202 |
| 11 | 2008-2009 | H1N1 | NC | Emergent, day 4 | P380N |
| 12 | 2008-2009 | H1N1 | NC | Emergent, day 7 | Y70C |
| 13 | 2008-2009 | H1N1 | 0.22 | Emergent, day 3 | V114I, E229G |
| 14 | 2008-2009 | H1N1 | NC | Emergent, day 2 | S105N |
| 15 | 2008-2009 | H1N1 | 1.7 | Emergent, day 6 | P389H |
| 16 | 2008-2009 | H3N2 | 0.61 | Nonemergent | Y155Hc |
| 17 | 2008-2009 | H3N2 | NC | Emergent, day 4 | G373R/G |