Table 1.
Antiviral and cytotoxic activitiesa of fluoxetine against various enteroviruses
| Virus | Species | Cell line | EC50 (μM) | CC50 (μM) |
|---|---|---|---|---|
| EV71 | HEV-A | RD | >40 | >40 |
| CVA16 | HEV-A | HeLa Rh | >40 | >40 |
| CVB3 | HEV-B | Vero | 3.36 ± 0.47 | 28 |
| E-1 | HEV-B | BGM | 3.93 ± 0.35 | 28 |
| E-9 | HEV-B | BGM | 4.58 ± 0.09 | 28 |
| E-11 | HEV-B | BGM | 5.76 ± 0.22 | 28 |
| PV1 | HEV-C | BGM | >28 | 28 |
| PV2 | HEV-C | BGM | >28 | 28 |
| PV3 | HEV-C | BGM | >28 | 28 |
| EV68 | HEV-D | HeLa R19 | 1.35 ± 0.08 | 29 |
| EV70 | HEV-D | HeLa R19 | 0.81 ± 0.06 | 29 |
| HRV-2 | HRV-A | HeLa Rh | >40 | >40 |
| HRV-14 | HRV-B | HeLa Rh | >40 | >40 |
a
Data are mean values ± standard deviations of at least three independent experiments.