Table 2.
Effect of serum on growth observed at high concentrations of echinocandins
| Species (no. of isolates) | Druga | Median (range) Emin (% growth) |
Median (range) % growth reduction | P value | |
|---|---|---|---|---|---|
| Without serum | With serum | ||||
| A. fumigatus (5) | CAS | 46.86 (42.5–68.45) | 8.28 (0–10.18) | 40.72 (67.26–32.75) | 0.002 |
| MICA | 56.38 (30.1–72.1) | 6.07 (0–11.85) | 50.26 (90.25–24.03) | 0.009 | |
| ANID | 50.55 (21.41–57.82) | 4.28 (0–13.55) | 40.84 (57.82–21.41) | 0.003 | |
| A. flavus (5) | CAS | 25.54 (19.37–28.63) | 8.14 (3.81–9.98) | 17.06 (21.93–11.58) | 0.001 |
| MICA | 35.19 (27.52–37.52) | 5.43 (0–5.6) | 29.75 (37.52–22.33) | 0.000 | |
| ANID | 27.13 (24.14–32.29) | 7.36 (4.08–14.14) | 18.15 (25.21–16.48) | 0.000 | |
| A. terreus (5) | CAS | 34.28 (30.6–43.33) | 20.93 (14.2–23.79) | 13.85 (29.13–6.94) | 0.017 |
| MICA | 36.63 (29.24–45.48) | 10.91 (4.49–20.87) | 28.63 (32.14–7.91) | 0.008 | |
| ANID | 36.36 (27.84–42.21) | 21.98 (15.83–25.95) | 10.82 (16.85–9.25) | 0.001 | |
a
CAS, caspofungin; MICA, micafungin; ANID, anidulafungin.