Table 5.
Population pharmacokinetic results in patients with hospital-acquired pneumonia (base/final model parameter estimates)
| Parametera | Estimate | Relative SE, % | Interindividual variability, % | 90% CIb |
|---|---|---|---|---|
| CL (liters/h) | 22.6 | 6.99 | 39.2 | 19.4, 26.4 |
| Vc (liters) | 108 | 26.6 | 158 | 33.3, 184 |
| Q (liters/h) | 55.1 | 10.3 | 44.1, 67.2 | |
| Vp (liters) | 190 | 16.3 | 141, 310 | |
| Residual variability | 22.1% | |||
| ηCL shrinkage | 5. 7% | |||
| ηVc shrinkage | 12.7% | |||
| ϵ shrinkage | 17.8% |
a
CL, clearance; Q, intercompartmental clearance; Vc, volume of distribution; Vp, volume of plasma compartment.
b
Confidence intervals (CI) calculated from bootstrap values.