Table 2.

Rifampin-dependent mouse parameters

Parameter (units)	Abbreviation	Distributiona	Mean	CVb	Sourcec
Fractional absorption	Fa	C	1.0	–d	27
Oral absorption rate (1/h)	ka	L	1.61	0.3	27
Total blood clearance (liters/h/kg0.75)	CLC	L	0.04	0.3	27
Fractional renal clearance	fR	L	0.19	0.3	26
Gut reabsorption rate (1/h)	kr	L	0.17	0.3	Fit (present study)
Partition coefficients
Lung/blood	PLU	L	0.49	0.2	27
Brain/blood	PBR	L	0.11	0.2	29
Fat/blood	PF	L	0.34	0.2	38
Heart/blood	PH	L	0.74	0.2	37, 38
Muscle/blood	PM	L	0.76	0.2	38
Bone/blood	PB	L	0.22	0.2	39
Skin/blood	PSK	L	0.76	0.2	38
Kidney/blood	PK	L	0.59	0.2	27
Spleen/blood	PS	L	0.25	0.2	28
Gut/blood	PG	L	0.74	0.2	29
Liver/blood	PL	L	3.1	0.2	27
Carcass/blood	PCR	L	0.59	0.2	Median (present study)

^aL, lognormal; C, constant.

^bCoefficient of variation. CV = SD/mean.

^cSources of the mean values.

^dNo variation.