Table 1.

Summary of the individual fitted PD parameters determined using a two-stage approach and population approach^a

Analysis and type of value	E0	Emax	H	EC50 (mg/liter)	r2	%fT>MIC (%) associated with:
						Stasis	Reductionb of:
							1 log	2 logs
Population					0.978
Minimum	1.90	4.36	0.670	16.9		5.23	11.9	16.1
Maximum	2.41	9.5	5.67	53.1		54.4	71.3	153
Median	2.13	5.71	2.35	30.6		25.2	30.9	42.8
Mean	2.12	6.03	2.65	32.4		25.7	34.9	53.0
SD	0.118	1.19	1.22	9.45		12.3	16.3	33.8
CV%	5.6	19.7	46.1	29.2		48.0	46.7	63.8
Two stage
Minimum	1.36	3.64	1.00	8.04	0.906	5.11	9.50	12.3
Maximum	3.00	10.0	5.63	69.1	1.00	58.7	83.8	131
Median	2.12	6.21	1.93	32.7	0.991	26.6	33.7	42.5
Mean	2.13	6.44	2.65	37.8	0.977	26.4	36.9	51.3
SD	0.441	1.81	1.56	19.3	0.027	13.4	19.2	29.8
CV%	20.7	28.0	58.6	48.2	2.8	50.7	51.8	58.2

^ar² values were derived from the individual predicted values versus observations.

^bReduction in bacterial burden.