Table 3.
Statistical summary of the individual fitted population PD parameters and calculated targets associated with static and 2-log bacterial reduction by species (n ≥ 3)
| Species and type of value | Emax | EC50 (mg/liter) | H | %fT>MIC (%) associated with: |
|
|---|---|---|---|---|---|
| Stasis | 2-log reductiona | ||||
| E. coli (n = 3) | |||||
| Minimum | 4.36 | 31.9 | 2.33 | 27.1 | 42.7 |
| Maximum | 5.50 | 53.1 | 3.84 | 54.4 | 152 |
| Median | 5.47 | 34.4 | 3.77 | 28.4 | 52.2 |
| Mean | 5.13 | 39.8 | 3.31 | 36.6 | 82.3 |
| CV% | 13.0 | 29.1 | 25.7 | 42.0 | 73.6 |
| K. pneumoniae (n = 4) | |||||
| Minimum | 4.60 | 37.5 | 1.38 | 31.6 | 55.2 |
| Maximum | 5.34 | 49.3 | 3.90 | 47.7 | 108 |
| Median | 5.00 | 41.9 | 3.26 | 36.0 | 83.6 |
| Mean | 4.98 | 42.6 | 2.95 | 37.8 | 82.6 |
| CV% | 6.10 | 12.0 | 38.0 | 18.6 | 32.4 |
| S. aureus (n = 3) | |||||
| Minimum | 5.27 | 25.3 | 2.38 | 21.2 | 30.3 |
| Maximum | 5.94 | 39.0 | 5.66 | 33.1 | 66.9 |
| Median | 5.49 | 27.6 | 3.92 | 25.1 | 33.0 |
| Mean | 5.57 | 30.6 | 4.00 | 26.5 | 43.4 |
| CV% | 6.10 | 23.9 | 41.2 | 22.9 | 47.0 |
| S. pneumoniae (n = 7) | |||||
| Minimum | 5.97 | 16.9 | 0.670 | 5.23 | 16.1 |
| Maximum | 9.15 | 30.9 | 2.37 | 22.3 | 44.3 |
| Median | 7.49 | 22.8 | 1.86 | 12.9 | 26.3 |
| Mean | 7.29 | 24.3 | 1.70 | 14.0 | 29.8 |
| CV% | 14.4 | 20.9 | 32.9 | 45.4 | 34.7 |
a
Reduction in bacterial burden (representative of bactericidal activity).