Table 4.
Final multivariable logistic regression model of factors associated with 30-day mortality in SAB (n = 182)a
| Variableb | Univariable analysis P value | Multivariable analysis |
||
|---|---|---|---|---|
| OR | 95% CI | P value | ||
| Age ≥ 70 years | 0.008 | 3.61 | 1.59–8.17 | 0.002 |
| Male sex | 0.163 | |||
| Pneumonia | 0.174 | |||
| Sepsis syndrome | 0.029 | 3.24 | 1.16–9.08 | 0.025 |
| Vancomycin AUC/MIC > 373 | 0.043 | 0.44 | 0.20–0.99 | 0.049 |
| Elevated vancomycin MICc | 0.063 | |||
| CWI ≥ 3 | 0.170 | |||
| Pitt bacteremia score ≥ 4 | 0.001 | 3.74 | 1.64–8.56 | 0.002 |
| Immunosuppression | 0.019 | |||
a
Abbreviations: OR, odds ratio; CI, confidence interval; AUC, area under the concentration-time curve; DNR, do not resuscitate; APACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; CWI, Charlson weighted index of comorbidity.
b
Variables that were significant on univariable analysis that were not considered for multivariable analysis were presence of DNR order (direct effect on outcome), an APACHE II score of ≥18, a SAPS II of >45, and heart disease and malignancy (collinearity).
c
Elevated vancomycin MIC defined as an Etest value of >1.5 mg/liter.