Table 4.
In vitro antifungal activities of efinaconazole and four reference drugs against a variety of fungal speciesa
| Organism (no. of isolates) | MIC (μg/ml) [geometric mean (range)]b |
||||
|---|---|---|---|---|---|
| Efinaconazole | Terbinafine | Ciclopirox | Itraconazole | Amorolfine | |
| Dermatophytes | |||||
| Trichophyton ajelloi (2) | 0.044 (0.031–0.063) | 0.046 (0.016–0.13) | 0.25 (0.25) | 0.35 (0.25–0.5) | 0.5 (0.25–1) |
| Trichophyton schoenleinii (1) | NC (0.0039) | NC (0.0039) | NC (0.25) | NC (0.13) | NC (0.016) |
| Trichophyton tonsurans (1) | NC (0.016) | NC (0.016) | NC (0.25) | NC (0.13) | NC (0.25) |
| Trichophyton verrucosum (1) | NC (0.0039) | NC (0.016) | NC (0.13) | NC (0.016) | NC (0.25) |
| Microsporum canis (2) | 0.18 (0.13–0.25) | 0.13 (0.063–025) | 0.25 (0.25) | 0.35 (0.25–0.5) | >4.0 (>4) |
| Microsporum cookei (1) | NC (0.5) | NC (0.13) | NC (0.25) | NC (0.5) | NC (0.5) |
| Microsporum gypseum (3) | 0.010 (0.0039–0.016) | 0.050 (0.031–0.063) | 0.31 (0.25–0.5) | 0.1 (0.031–0.25) | 0.08 (0.063–0.13) |
| Epidermophyton floccosum (3) | ≤0.005 (≤0.002–0.0078) | 0.039 (0.031–0.063) | 0.31 (0.25–0.5) | 0.08 (0.063–0.13) | 0.16 (0.13–0.25) |
| Yeasts | |||||
| Candida glabrata (7) | 0.026 (0.0039–0.13) | >8 (>8) | 0.13 (0.13) | 0.74 (0.25–2) | >4.9 (2–>8) |
| Candida krusei (10) | 0.024 (0.0078–0.063) | >8 (>8) | 0.21 (0.13–0.25) | 0.38 (0.13–0.5) | 0.27 (0.13–0.5) |
| Candida parapsilosis (13) | ≤0.0046 (≤0.002–0.016) | 0.28 (0.13–1) | 0.22 (0.13–0.5) | 0.13 (0.063–0.25) | 0.56 (0.13–4) |
| Candida tropicalis (10) | 0.014 (0.0078–0.063) | >8 (>8) | 0.5 (0.5) | 0.31 (0.063–0.5) | NC (≤0.016–>8) |
| Candida guilliermondii (1) | NC (0.016) | NC (1) | NC (0.25) | NC (0.13) | NC (0.25) |
| Candida kefyr (1) | NC (≤0.002) | NC (2) | NC (0.13) | NC (0.031) | 0.063 |
| Candida lusitaniae (1) | NC (0.0039) | NC (4) | NC (0.25) | NC (0.13) | 0.5 |
| Cryptococcus neoformans (5) | ≤0.0023 (0.002–0.0039) | 0.25 (0.063–0.5) | ≤0.031 (≤0.016–0.063) | 0.041 (0.031–0.063) | ≤0.064 (≤0.016–0.13) |
| Trichosporon asahii (3) | ≤0.005 (≤0.002–0.0078) | 0.63 (0.5–1) | 0.13 (0.13) | 0.1 (0.063–0.13) | 0.08 (0.063–0.13) |
| Trichosporon beigeleii (2) | 0.016 (0.0078–0.031) | 0.5 (0.5) | 0.18 (0.13–0.25) | 0.18 (0.13–0.25) | 0.35 (0.25–0.5) |
| Nondermatophytes | |||||
| Acremonium potronii (3) | 0.31 (0.25–0.5) | 0.25 (0.13–0.5) | 0.25 (0.13–0.5) | >2.5 (1–>4) | 0.26 (0.13–1) |
| Acremonium sclerotigenum (2) | 0.18 (0.13–0.25) | 0.09 (0.063–0.13) | 1.4 (1–2) | >4 (>4) | 1 (1) |
| Fusarium oxysporum (3) | 1 (0.5–2) | 2.5 (1–4) | 1 (1) | >4 (>4) | >4 (>4) |
| Fusarium solani (1) | NC (0.5) | NC (4) | NC (>4) | NC (>4) | NC (>4) |
| Paecilomyces variotii (1) | NC (0.0078) | NC (0.25) | NC (0.25) | NC (0.13) | NC (>4) |
| Paecilomyces lilacinus (3) | 0.031 (0.031) | 0.1 (0.063–0.13) | 4 (4) | 1.6 (1.0–4) | 0.25 (0.25) |
| Pseudallescheria boydii (1) | NC (0.063) | NC (>4) | NC (4) | NC (>4) | NC (4) |
| Scopulariopsis brevicaulis (4) | 0.25 (0.13–0.5) | 1 (0.5–2) | 0.59 (0.5–1) | >4 (>4) | 0.09 (0.063–0.13) |
| Scopulariopsis brumptii (1) | NC (0.13) | NC (1) | NC (0.5) | NC (>4) | NC (0.5) |
| Aspergillus fumigatus (4) | 0.089 (0.031–0.5) | 1.4 (1–2) | 0.42 (0.25–0.5) | 0.5 (0.25–1) | >4 (>4) |
| Aspergillus flavus (4) | 0.11 (0.063–0.13) | 0.11 (0.063–0.5) | >3.4 (2–>4) | 0.18 (0.13–0.25) | >4 (>4) |
| Aspergillus niger (3) | 0.2 (0.13–0.25) | 0.16 (0.13–0.25) | 0.63 (0.5–1) | 0.63 (0.5–1) | >4 (>4) |
| Aspergillus sydowii (4) | 0.037 (0.0078–0.25) | 0.076 (0.063–0.13) | 0.59 (0.5–1) | >0.3 (0.063–>4) | >4 (>4) |
| Aspergillus terreus (4) | 0.09 (0.063∼0.13) | 0.13 (0.13) | 0.5 (0.25–1) | 0.21 (0.13–0.25) | >4 (>4) |
| Aspergillus nidulans (4) | 0.0078 (0.0078) | 0.063 (0.063) | 1 (0.5–4) | 0.089 (0.063–0.25) | >4 (>4) |
a
ATCC or Japanese repository isolates.
b
MIC geometric means are calculated for species with at least 2 isolates tested; NC, not calculated. MIC is presented instead of MIC range for species with one isolate tested.