Table 1.
Neuraminidase properties of the recombinant pandemic A/Québec/144147/09 viruses
| Virus | IC50a (nM [ratio]) of: |
Kma (μM [ratio]) | Vmaxa (U/s [ratio]) | Plaque areab (mm2) | |
|---|---|---|---|---|---|
| Oseltamivir | Zanamivir IC50a nM [ratio]) | ||||
| WT | 0.46 ± 0.02 (1) | 0.15 ± 0.01 (1) | 80.9 ± 17.5 (1) | 269.9 ± 4.3 (1) | 0.50 ± 0.13 |
| E119G | 1.52 ± 0.13 (3.3) | 123.1 ± 21.7 (821) | 690.2 ± 37.3 (8.5) | 238.1 ± 6.6 (0.9) | 0.33 ± 0.11* |
| Q136K | 0.08 ± 0.01 (0.2) | 112.3 ± 15.8 (749) | 16.6 ± 0.9 (0.2) | 20.5 ± 3.5 (0.1) | 0.42 ± 0.14 |
a
Values indicate means ± standard deviations from 3 experiments. Ratios are from comparisons to the recombinant wild-type (WT) virus.
b
Values indicate means ± standard deviations from 20 measures. *, P < 0.05 compared to the WT virus by one-way ANOVA.